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KMID : 0370219980420020125
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Yakhak Hoeji
1998 Volume.42 No. 2 p.125 ~ p.131
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Isolation of Inhibitory Components on Tumor Necrosis Factor-α Production from Angelica Koreana
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조재열/Cho JY
이종수/박지수/박명환/Lee JS/Park JS/Park MH
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Abstract
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The total ethanol extract of Angelica koreana radix (UmbeUiferae) showed potent inhibitory effect on tumor necrosis factors (TNF-alpha) production from LPS-stimulated RAW 264.7 cells in screening studies on 118 Korean medicinal plants. The activity-guided fractionation of the total ethanol extract resulted in the isolation of 4 compounds, including active substances. The chemical structures of the compounds isolated were established by chemical and spectrometric analyses as imperatorin, isoimperatorin, osthol and oxypeucedanin. Among them, osthol, oxypeucedariin and isoimperatorin showed significant inhibitory activities on TNF-alpha production as 54.3+/-2.1%, 33.6+/-1.0% and 17.7+/-3.0%, respectively, at 12.5mcg/ml.
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